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Biotechnology/Chiral Chemistry |
Secondary
Protecting Agents
Carboxylic Acid and Carboxamide Protecting
Groups
 |
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Dmcp® Dimethylcyclopropylmethyl |
Dcmp® Dicyclopropylmethyl |
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Dmcp
and Dcpm Suggested Uses |
| •
C terminal protection - Dmcp for amide protection with 1% TFA removal - Dcpm for COOH where selective removal is necessary in the presence of tert Butyl- derived or N-Trityl side chain protection • Side chain protection using Dmcp - Dmcp in place of Trityl protection particularly with two amino acids a. Asparagine (Asn) b. Glutamine (Gln) |
•
N-Trityl asparagine, the N Terminal Asn removal is sluggish
in TFA. Dmcp will provide exceptional solvolytic
behavior • Rapid Continuous Solution Phase- Peptide Chemistry in combination with Fmoc or Bsmoc alpha amino Protectants for improved result |
